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KMID : 0391319960060020287
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Korean Journal of Biological Response Modifiers
1996 Volume.6 No. 2 p.287 ~ p.283
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Complete Remission in Adult Acute Leukemia Induced by Granulocyte Colony-Stimulating Factor(G-CSF)
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Abstract
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Background: Granulocyte colony-stimulating factor(G-CSF) has been known to induce proliferation of blasts in acute leukemia. But some authors reported the differentiation-inducing effect on lekemic blasts of G-CSF. Therefore, the objective of this study is to analyze the effects of recombinant human G-CSF(rhG-CSF) administration in patients with acute leukemia.
Methods: The one patient was diagnosed with acute lymphoblastic leukemia(ALL) and the other was acute myelogenous leukemia(AML). Severe pneumonia and neutropenia were coexisted in both patients. In both patients, G-CSF was administered daily by intravenous injection according to their clinical and hematological features. Bone marrow examination was performed before and after administration.
Results: In the first patient(ALL), absolute neutrophil counts(ANC) began to rise above 1000/mm3 since the 14th day of G-CSF administration. After the completion of G-CSF administration, the percentage of blasts was decreased. to 3% and complete remission was noted in bone marrow examination.
However, after three weeks, relapse was discovered in follow-up bone marrow examination. In the second patient(AML), ANC began to increase since the 4th day of G-CSF administration. After 10 days´ G-CSF administration, complete remission was noted in bone marrow examination until the duration of remission of second patient was 4 months.
Conclusions: G-CSF may be useful to the progression of acute leukemia and furthtr study will be required about the possibility of differentiation-inducing effects of G-CSF.
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KEYWORD
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G-CSF, Acute Leukemia, Complete remission
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